Posted: June 1st, 2023

post- monica craig

Respond in the following ways: (POSITIVE COMMENT)
Share insights on how the factor you selected( THE FACTOR I SELECTED IS ATTACHED BELLOW IN A DOCUMENT) impacts the pathophysiology of the disorder your colleague selected.
Expand on your colleague’s posting by providing additional insights or contrasting perspectives based on readings and evidence.

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To provide excellent patient care, practitioners must understand information at the cellular level.  A good history and physical are essential for proper diagnosing. Useful learning tips might be weekly outlines, reading resources, completion of available exercises, and taking notes on topics one might not understand.  Pertinent information to include when evaluating a patient is the complaint, the assessment, the diagnostics, treatment plan, and educating the patient (Laureate Education, 2012).
Cystic Fibrosis and the White Population
     Huether & McCance (2017) state 1:3000 cases of CF among the white population and Hammer & McPhee (2019) state 1:2000 cases of CF among the white population.  CF is very rare in Asians (Hammer & McPhee, 2019). 1 in every 29 whites in the United States is a carrier of CF (Huether & McCance, 2017).
Pathophysiology of Cystic Fibrosis
     Cystic Fibrosis (CF) is caused by an abnormal expression of the cystic fibrosis transmembrane conductance regulator (CFTCR) gene.  CF is considered an obstructive lung disease.  The defective chloride transporter gene is housed in the exocrine gland.  This faulty gene leads to water flow abnormality and results in viscous secretions primarily affecting the lungs but can also affect the reproductive organs and digestive tract as well (Huether & McCance, 2017).  Symptoms or signs that may present to aid in the diagnosis of CF might be a delayed passing of meconium in the infancy stage.  Foul-smelling, floating stool due to the malabsorption of fats could be a symptom.  A cough, pulmonary infections, failure to thrive, and dyspnea are additional signs (Berkowitz, 2007).  Intracellular change related to CF is the defective CFTCR gene.  
References
Berkowitz, A. (2007).  Clinical pathophysiology made ridiculously simple. Miami, FL:  MedMaster, Inc.
Hammer, G. D., & McPhee, S. J. (2019). Pathophysiology of disease: An introduction to clinical medicine (8th  ed.). New York, NY: McGraw-Hill Education.  
Huether, S. E., & McCance, K. L. (2017). Understanding  pathophysiology (6th ed.). St. Louis, MO: Mosby.
Laureate Education, Inc. (Executive Producer). (2012). Introduction to advanced pathophysiology. Baltimore, MD: Author.

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